Inhibitor crystalline form and preparation method and use thereof

摘要

The present invention relates to new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-one; the present invention also relates to methods for preparing the new crystalline forms of 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, pharmaceutical compositions containing the new crystalline forms thereof, and uses thereof for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.

主权项

1. A crystal Form IX of Idelalisib with the structural formula shown below, wherein, Form IX is a hydrate with 0.7 molecule of water; and Form IX is characterized by a X-ray powder diffraction pattern measured using Cu-Kα radiation, expressed as 2θ angles, having the following characteristic peaks: 8.8±0.2°, 11.0±0.2°, 13.9±0.2°, 14.9±0.2°, 16.2±0.2° and 20.6±0.2°.