| 发明名称 | Inhibitors of influenza viruses replication | ||
| 摘要 | Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I):; or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. | ||
| 申请公布号 | US9518056(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201514929634 | 申请日期 | 2015.11.02 |
| 申请人 | Vertex Pharmaceuticals Incorporated | 发明人 | Charifson Paul S.;Clark Michael P.;Bandarage Upul K.;Bethiel Randy S.;Court John J.;Deng Hongbo;Davies Ioana;Duffy John P.;Farmer Luc J.;Gao Huai;Gu Wenxin;Jacobs Dylan H.;Kennedy Joseph M.;Ledeboer Mark W.;Ledford Brian;Maltais Francois;Perola Emanuele;Wang Tiansheng;Wannamaker M. Woods;Byrn Randal;Zhou Yi;Lin Chao;Jiang Min;Jones Steven;Germann Ursula A.;Salituro Francesco G.;Kwong Ann Dak-Yee |
| 分类号 | C07D401/04;C07D401/00;C07D471/04;A61K31/506;C07D401/10;A61K31/5377;A61K31/55;A61K31/553;C07D239/30 | 主分类号 | C07D401/04 |
| 代理机构 | Honigman Miller Schwartz and Cohn LLP | 代理人 | Honigman Miller Schwartz and Cohn LLP ;Weber Andrew N.;O'Brien Jonathan P. |
| 主权项 | 1. A compound 1070: | ||
| 地址 | Boston MA US | ||