| 摘要 |
This patent describes a procedure dealing with a separation of (+)-2-(6-methoxy-2-naphtyl) propionic acid of the mixture which consists of (+) and (-)-2-(6-methoxy-2-naphtyl)propionic acid or the salts of them together with a procedure related to the preparation of (+)-2-(6-methoxy-2-naphtyl)propionic acid or its salts, while the mixture of these acids or the salts of them is prepared with the use of 50 up to 100 molar percent, according to the contain of acids, N-R-D glucamine, where R means C2-36 alkyl or C3-8 cycloalkyl or the salts of that in the inert solvent, in which the created salt of N-R-D-glucamine and (+)-2-(6-methoxy-2-naphtyl)propionic acid is less soluble, at the crystallisation temperature, than the salt of N-R-D glucamine with (+)-2-(6-methoxy-2-naphtyl)propionic acid and the salt of (+)-2-(6-methoxy-2-naphtyl propionic acid and N-R-D glucamine is let to crystallise or the created salt can be decomposed, while (+)-2-(6-methoxy-2-naphtyl)propionic acid is created and it is crystallised of the inert solvent or it can be changed in the salt which is suitable from pharmaceutical point of view. The prepared acid has an antipyretic, analgesic or counter inflammatory effect .
|
