发明名称 |
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES |
摘要 |
<p>Compounds of the formula (I):wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.</p> |
申请公布号 |
EP1100797(A1) |
申请公布日期 |
2001.05.23 |
申请号 |
EP19990963123 |
申请日期 |
1999.06.28 |
申请人 |
PFIZER LIMITED;PFIZER INC. |
发明人 |
KEMP, MARK IAN;PALMER, MICHAEL, JOHN;SANNER, MARK, ALLEN;WYTHES, MARTIN, JAMES |
分类号 |
A61K31/44;A61K31/4427;A61K31/454;A61K31/4545;A61K31/4709;A61P19/00;A61P21/00;A61P21/04;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P27/16;A61P37/00;A61P43/00;C07D235/24;C07D401/04;C07D401/14;C07D413/04;C07D413/14;C07D417/04;C07D417/14;C07D471/04;C07D471/14;C07D521/00;(IPC1-7):C07D413/14 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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