发明名称 |
In vitro method for characterizing the metabolic stability of a hyperpolarized drug candidate |
摘要 |
The invention relates to an NMR based method for characterising the metabolic stability of a drug candidate comprising enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed "hyperpolarisation") contacting the drug candidate with liver cells or cell organelles and carrying out NMR analysis.
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申请公布号 |
EP1544634(A1) |
申请公布日期 |
2005.06.22 |
申请号 |
EP20040029329 |
申请日期 |
2004.12.10 |
申请人 |
AMERSHAM HEALTH AS |
发明人 |
LERCHE, MATHILDE H.;GOLMAN, KLAES |
分类号 |
G01N24/12;C12Q1/02;G01N33/15;G01N33/50;G01R33/28;G01R33/32;G01R33/465;G01R33/62;(IPC1-7):G01R33/465 |
主分类号 |
G01N24/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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