LSA-5 pre-erythrocytic stage antigen of plasmodium falciparum, immunogenic composition comprising said antigen, and vaccines against malaria

摘要

The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterisation of a novel liver and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90 %). The invention concerns antigenic peptides or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic compositions, vaccines and kits comprising these.