RSK INHIBITORS AS ANTI-SEPTICEMIA AGENTS

摘要

A composition comprising a RSK activity inhibiting agent is provided for use in preventing or treating septicemia. Inhibition of RSK activity has been found by applicant to inhibit pathogenic stimulated expression of adhesion factors in endothelial cells and the pathogenic stimulated expression of nitric oxide synthase by macrophages. The RSK specific inhibitors used in accordance with the disclosed composition and methods can be selected from any inhibiting moiety including but not limited to anti-sense oligonucleotides, interfering oligonucleotide and kaempferol 3-O-(3",4"-di-O-acetyl-a-L-rhamnopyranoside) and related compounds.