| 摘要 |
<p>The present invention relates to novel compounds of formula (I)', pharmaceutically acceptable salts, prodrugs or solvates thereof wherein R1 is hydrogen or C1-4 alkyl; R2 is an a or ß naphthyl group, optionally substituted by 1 or 2 groups R8, each of them being the same or different; R8 is selected from a group consisting of: halogen, cyano, C1-4alkyl; R5 is hydrogen or C1-4 alkyl; R6 is hydrogen or C1-4 alkyl; R7 is selected in the group consisting of: hydrogen, fluorine, and C1-4 alkyl; or corresponds to X, X1, X2 or X3; wherein X corresponds to (I)'a X1 corresponds to (I)'b X2 corresponds to (I)'c X3 corresponds to (I)'d R3 is hydrogen or C1-4 alkyl; or corresponds to X or X1; R4 is hydrogen or C1-4 alkyl; or corresponds to X or X1; R9 is C1-4alkyl; R10 is hydrogen, C1-4alkyl, C3-6cycloalkyl or C3-6cycloalkylC1-3alkyl; R11 is haloC1-2alkyl; n is 1 or 2; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as serotonin (5-HT), dopamine (DA) and norepinephrine (NE), re-uptake inhibitors.</p> |
