| 发明名称 |
Inhibiting the transient receptor potential A1 ion channel |
| 摘要 |
This disclosure describes novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain and respiratory conditions. |
| 申请公布号 |
US9394308(B2) |
申请公布日期 |
2016.07.19 |
| 申请号 |
US201414160333 |
申请日期 |
2014.01.21 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Li Qingyi;Cheng Lily;Liu Christopher M.;Wrona Iwona E.;Lippa Blaise S.;Metcalf, III Chester A.;Jackson Andrew J.;Chapman Lauren M. |
| 分类号 |
C07D473/08;C07F9/6561 |
主分类号 |
C07D473/08 |
| 代理机构 |
|
代理人 |
MacMillan Keith D.;Todaro John C. |
| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein,
R1 is hydrogen or —CH2—R1a, wherein R1a is a phosphate moiety;R2 is CH3;R3 is CH3; andA is N or CH. |
| 地址 |
Rahway NJ US |
