发明名称 |
Injectable nano-network gels for diabetes treatment |
摘要 |
A system for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through an injectable nano-network consisting of oppositely-charged dextran nanoparticles encapsulating insulin and glucose-specific enzymes forming a gel-like 3D scaffold. As demonstrated by the examples, the system effectively dissociates to release insulin in a hyperglycemic condition, where the catalytic conversion of glucose into gluconic acid and the subsequent degradation of polymeric matrix are facilitated. This formulation design provides a delivery strategy for both self-regulated and long-term diabetes management. |
申请公布号 |
AU2014260024(B2) |
申请公布日期 |
2016.09.15 |
申请号 |
AU20140260024 |
申请日期 |
2014.04.29 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
ANDERSON, DANIEL G.;GU, ZHEN;AIMETTI, ALEX ARTHUR;LANGER, ROBERT S. |
分类号 |
A61K38/28 |
主分类号 |
A61K38/28 |
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