Rapid detection of analytes in liquid samples

摘要

A device for detecting at least one analyte (and in some embodiments two, three, or four or more different analytes) in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid therein, wherein said chamber is an elongate chamber having a length axis; (ii) a carrier or agitator in said elongate chamber, said carrier or agitator having opposite end portions and a side portion, the carrier or agitator dimensioned to travel in said chamber along said length axis and/or permit said liquid sample to flow in the chamber therearound, either (or both) thereby agitating the liquid sample; and (iii) at least one anti-analyte antibody coupled to either the carrier and/or the chamber side wall.

主权项

1. A device for detecting at least one analyte in a liquid sample, comprising:
(a) a support having a chamber for receiving a liquid sample therein, wherein said chamber is an elongate chamber having a length axis and a side wall portion; (b) a carrier in said elongate chamber, said carrier having opposite end portions and a side portion, said carrier dimensioned to travel in said chamber along said length axis, and/or permit flow of said liquid sample in said chamber around said carrier to thereby agitate said liquid sample; and (c) at least one anti-analyte antibody coupled to either said carrier or to said chamber side wall portion, each at least one analyte being specifically bound by a different antibody of each of said at least one anti-analyte antibody; wherein said chamber has an internal length dimension and said carrier has an external length dimension, wherein said chamber internal length dimension is at least twice that of said carrier length dimension; and wherein said carrier has a density greater than, or less than, said liquid sample.