Antiviral pyrrolopyridine derivatives and method for preparing the same

摘要

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

主权项

1. A compound represented by the following Chemical Formula I, a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: wherein, in the formula, R2 is tert-butoxy; R6 is hydrogen, or —(CH2)n—R7; R7 is hydrogen; halogen; hydroxy; amino; cyano; trifluoromethyl; C2-6 alkenyl; C2-6 alkynyl; C1-6 alkoxy; carbamoyl; CONH(C1-3 alkyl); CON(C1-3 alkyl)2; COOH; C3-6 cycloalkyl unsubstituted or substituted with 1 or 2 substituents each selected from the group consisting of halogen, cyano, hydroxy, hydroxymethyl, carboxy and carbamoyl; phenyl unsubstituted or substituted with 1 to 3 substituents each selected from the group consisting of cyano, C1-6 alkyl, C1-6 alkoxy and amino; pyridinyl unsubstituted or substituted with 1 or 2 substituents each selected from the group consisting of halogen, cyano, C1-6 alkyl, C1-6 alkoxy and amino; pyrimidinyl unsubstituted or substituted with amino or halogen; dioxoisoindolinyl; oxazolyl; furanyl unsubstituted or substituted with C1-6 alkyl or halogen; thiophenyl unsubstituted or substituted with C1-6 alkyl or halogen; pyrrolidinyl unsubstituted or substituted with C1-6 alkyl or halogen; 2-oxopyrrolidinyl; pyrazolyl unsubstituted or substituted with C1-3 alkyl; or thiazolyl; and n is an integer of 1 to 5.