发明名称 Process for the separation of folinic acids
摘要 PCT No. PCT/EP93/00127 Sec. 371 Date Aug. 16, 1993 Sec. 102(e) Date Aug. 16, 1993 PCT Filed Jan. 20, 1993 PCT Pub. No. WO93/15076 PCT Pub. Date Aug. 5, 1993.The treatment of racemic calcium folinate with a sodium salt of ethylendiaminotetraacetic acid and, preferably, calcium cloride determines the separation of a precipitate, whose mother liquors result enriched in a calcium salt of the levofolinic acid, purifiable through repeated crystallizations.
申请公布号 US5391738(A) 申请公布日期 1995.02.21
申请号 US19930104129 申请日期 1993.08.16
申请人 APR APPLIED PHARMA RESEARCH S.A. 发明人 VECCHI, GUISEPPE
分类号 C07D475/04;(IPC1-7):C07D475/04 主分类号 C07D475/04
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