发明名称 |
Derivatives of 3-hydroxy-4-(cyclyl-alkylaminoalkyl)-5-phenyl-1h-pyrazole as antagonists of the gonadotropin releasing hormone (gnrh) for use in the treatment of sex hormone related conditions, such as prostatic of uterine cancer |
摘要 |
The invention relates to a group of novel pyrazole compounds of Formula (I): wherein: R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, M and R<SUP>5 </SUP>are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
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申请公布号 |
US2006287379(A1) |
申请公布日期 |
2006.12.21 |
申请号 |
US20050524977 |
申请日期 |
2005.11.28 |
申请人 |
ASTRAZENECA AB |
发明人 |
BIRD THOMAS G.;MAUDET MICKAEL L.;HERDEMANN MATTHIAS F. |
分类号 |
A61K31/416;A61K31/4155;A61K31/4196;A61K31/4439;A61K31/4725;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61K31/541;C07D231/20;C07D231/22;C07D401/12;C07D401/14;C07D403/02;C07D403/12;C07D405/02;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D487/08;C07D491/04;C07D519/00 |
主分类号 |
A61K31/416 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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