Use of t-Bu QuinoxP

摘要

A process of preparing an optically active allyl compound comprising asymmetrically coupling an allyl compound with an organic nucleophilic compound in the presence of a catalyst. Preferably, the nucleophile is a malonate compound or an amine. The preferred allylic compound is 1,3-diphenyl-2-propenyl acetate. The catalyst is preferably a transition metal complex compound having a phosphine ligand. The transition metal is preferably palladium. The phosphine ligand is preferably a 2,3-bis(dialkylphosphino)pyrazine derivative. The pyrazine derivative is preferably a quinoxaline derivative, more preferably a compound of formula (V): wherein * is an asymmetric centre, R6 and R7 are each independently an optionally substituted alkyl group, R8 and R9 are each independently selected from hydrogen, an optionally substituted alkyl group and a ring system, or R8 and R9 are taken together to form a fused ring.