发明名称 |
STABILIZATION OF FC-CONTAINING POLYPEPTIDES |
摘要 |
This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides. |
申请公布号 |
EP3027647(A2) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20140832297 |
申请日期 |
2014.07.30 |
申请人 |
AMGEN INC. |
发明人 |
KANNAN, GUNASEKARAN;LAVALLEE, JENNIFER;JACOBSEN, FREDERICK W. |
分类号 |
C07K16/00;A61K38/18;C07K14/475 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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