Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline

摘要

One aspect of the invention relates to a biocompatible medical product comprising at least 1% by weight of dry matter of a covalently cross-linked polymer that is obtained by reacting a nucleophilically activated polyoxazoline (NU-POX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-POX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m≧2, n≧2 and m+n≧5; and wherein the NU-POX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate. Also provided is a kit for producing the aforementioned biocompatible cross-linked polymer. The biocompatible cross-linked polymers according to the invention have excellent implant and/or sealing characteristics.

主权项

1. A biocompatible tissue-adhesive medical product selected from the group consisting of adhesive tissue tape, an adhesive tissue film, a tissue sealant, a haemostatic material, a suture material, a polymer coated stent and an implant, comprising at least 1% by weight of dry matter of a covalently cross-linked polymer obtained by reacting a nucleophilically activated polyoxazoline (NU-PDX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-PDX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m≧2, n≧2 and m+n≧5; wherein the total number of reacted and unreacted electrophilic groups contained in the polymer exceeds the total number of reacted and unreacted nucleophilic groups contained in the polymer by at least 3%; wherein the NU-PDX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate, and wherein the tissue-adhesive properties derive from a reaction of non-reacted electrophilic groups in the cross-linked polymer with nucleophilic groups present in the tissue.