Morphan and morphinan analogues, and methods of use

摘要

The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein
R1 is cyclobutyl or R2 is H or methoxy; and R3 and R4 are each, independently, H, hydroxyl, or NR5R6 wherein R5 and R6 are each independently H, alkyl, or substituted acyl, or alternatively, R3 and R4, together with the carbon atom to which they are attached, form C═O or C═CH2.