Polymeric biomaterials derived from phenolic monomers and their medical uses

摘要

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogs, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

主权项

1. A biocompatible polymer comprising a tyrosol recurring unit, and having the following formula: wherein y1 is 0, 1, 2, 3, or 4; X1 is bromine (Br) or iodine (I); and R4a is selected from the group consisting of C1-C30 alkylene, C2-C30 alkenylene, C2-C30 alkynylene, C1-C30 heteroalkylene, C2-C30 heteroalkenylene, C2-C30 heteroalkynylene, C6-C30 arylene, C7-C30 alkylarylene, C8-C30 alkenylarylene, C8-C30 alkynylarylene, and C2-C30 heteroarylene.