| 发明名称 | Methods and compositions for modulation of blood-neural barrier | ||
| 摘要 | Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist. | ||
| 申请公布号 | US9487579(B2) | 申请公布日期 | 2016.11.08 |
| 申请号 | US201414282808 | 申请日期 | 2014.05.20 |
| 申请人 | LUDWIG INSTITUTE FOR CANCER RESEARCH;UNIVERSITY OF MARYLAND;THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 发明人 | Eriksson Ulf;Fredriksson Linda;Lawrence Daniel;Su Enming;Yepes Manuel;Strickland Dudley |
| 分类号 | C07K16/18;C07K16/22;A61K39/395;C07K14/475;A61K39/00 | 主分类号 | C07K16/18 |
| 代理机构 | Fox Rothschild LLP | 代理人 | Fox Rothschild LLP |
| 主权项 | 1. A method for treating neural edema in a higher vertebrate animal in need of such treatment comprising administering to said animal an effective amount of an anti-PDGF-CC antibody or an anti-PDGF-C antibody. | ||
| 地址 | New York NY US | ||