发明名称 |
SALES DE ADICION DE ACIDO, HIDRATOS Y POLIMORFOS DE LA ETIL-AMIDA DEL ACIDO 5-(2,4-DIHIDROXI-5-ISOPROPIL-FENIL)-4-(4-MORFOLIN-4-IL-METIL-FENIL)-ISOXAZOL-3-CARBOXILICO, Y FORMULACIONES QUE COMPRENDEN ESTAS FORMAS |
摘要 |
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.
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申请公布号 |
PE01662009(A1) |
申请公布日期 |
2009.03.14 |
申请号 |
PE20080041820 |
申请日期 |
2008.02.29 |
申请人 |
NOVARTIS AG;VERNALIS (RANDD) LTD. |
发明人 |
DRYSDALE MARTIN JAMES;DYMOCK BRIAN WILLIAM;KRELL CHRISTOPH;MUTZ MICHAEL;PETERSEN HOLGER;ZHENG WEIJIA |
分类号 |
A61K31/5375;A61K31/5377;A61P35/00;C07D295/00 |
主分类号 |
A61K31/5375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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