PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF

摘要

Disclosed is a pyrido-azaheterecydic compound as shown in the following formula I, an isomer and pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof, a preparation method thereof and compositions containing the compound, and the use thereof as multi-target protein kinase inhibitors in the preparation of drugs for treating neoplastic diseases, etc., and protein kinases, in particular for c-Met related diseases. The compound represented by formula (I) has a highly effective inhibiting activity on tumor cells in which c-Met kinase highly expressed, and can effectively target the signaling pathway mediated by c-Met, so that same can be used in the treatment of tumors and other related diseases induced by overexpression of c-Met.