Systems and methods for promoting wound healing

摘要

In various embodiments, provided are topical gas delivery systems and methods for promoting wound healing. A provided gas delivery system comprises a gas reservoir comprising at least one chamber adapted to contain one or more therapeutic gases selected from NO, CO, O2, air, or combinations thereof, and at least one gas permeable membrane operably coupled to the reservoir. A provided method comprises using a provided gas delivery system to deliver the one or more therapeutic gases to a wound site such that a NO/ONOO− ratio suitable for promoting wound healing is achieved at the wound site.

主权项

1. A system for controlled delivery of therapeutic gases to a wound site to promote wound healing, comprising:
a gas reservoir comprising a first chamber for containing a first therapeutic gas comprising NO, and optionally further comprising CO; and a second chamber for containing a second therapeutic gas comprising O2, and optionally further comprising CO; wherein the reservoir maintains a separation of a contained first therapeutic gas from a contained second therapeutic gas; at least one gas permeable membrane for controlling diffusion of a contained therapeutic gas from the reservoir to the wound site, the at least one gas permeable membrane operably connected to the gas reservoir; wherein the system maintains a space between the wound site and the at least one gas permeable membrane when the system is applied to a wound site; and wherein the system delivers, when the system is applied to a wound site, the contained therapeutic gases such that a NO/ONOO− ratio suitable for promoting wound healing is achieved at the wound site.