N-DEACETYLTHIOCOLCHICINE DERIVATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM

摘要

Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: - the linker is a bivalent straight or branched C₁-C₈ alkyl residue, C₃-C₈ cycloalkyl, a phenylene or heterocyclic C₄-C₆ ring; - the G₁ and G₂ junctions, which can be the same or different, are -CO-, -CONH-, -CR₂- groups in which R is hydrogen or a straight C₁-C₄ alkyl residue, or the G₁-linker-G₂ group is the -CO- group with the proviso that when G₁ and G₂ are both CO, or when G₁ is -CONH- and G₂ is -CO-, the linker is different from a bivalent alkyl residue. The compounds of formula (I) have antiproliferative, antinflammatory, antiarthritic and antiviral activity.