A PHARMACEUTICAL COMPOSITION CONTAINING OLANZAPINE AS THE ACTIVE AGENT AND A PROCESS FOR THE PREPARATION THEREOF

摘要

A pharmaceutical composition containing, as the active agent, olanzapine and further a filler and auxiliary substances, in the form of tablet obtainable by direct tabletting, the core of the tablet containing olanzapine in an amount of 0.5 to 20 w.% and a pharmaceutically acceptable filler in an amount of 35 to 99 w.%, preferably up to 95 w.%, with the particle sizes ranging from 10 to 1000 µm, preferably from 50 to 400 µm, the core being optionally coated, in which case the coating contains 1 to 10 w.% of polyethyleneglycol after drying. The pharmaceutically acceptable filler is selected from the series of microcrystalline cellulose, lactose, the polyalcohols mannitol or sorbitol, calcium hydrogenphosphate, and a combination of microcrystalline cellulose with a mono- or oligosaccharide or polyalcohol. A process for the preparation of tablets is also disclosed.