Methods and compounds for reducing intracellular lipid storage

摘要

Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.

主权项

1. A method for reducing intracellular lipid accumulation in a cell comprising contacting the cell in vitro or in vivo with an effective amount of a compound selected from Table 3, wherein the effective amount of the compound shifts cellular energy metabolism from fatty acid oxidation to glycolysis, thereby reducing intracellular lipid accumulation within the cell, wherein the cell has reduced Adipose Triglyceride Lipase (ATGL) function due to a loss of function mutation in the gene PNPLA2.