发明名称 |
TM4SF1 BINDING PROTEINS AND METHODS OF USING SAME |
摘要 |
This present invention relates to compounds (e.g., TM4SF1 binding proteins, e.g., anti-TM4SF1 antibodies) that specifically bind to a polypeptide at an epitope including an amino acid sequence of SEQ ID NO: 1. In particular, the compounds of the invention are capable of being internalized into a TM4SF1-expressing cell (e.g., a tumor cell or an angiogenic vasculature endothelial cell) following binding to the epitope of including the amino acid sequence of SEQ ID NO: 1. The invention also provides methods of treating a subject having a disorder associated with pathological angiogenesis with the compounds of the invention. |
申请公布号 |
US2016229910(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
US201615092486 |
申请日期 |
2016.04.06 |
申请人 |
Beth Israel Deaconess Medical Center, Inc. |
发明人 |
JAMINET Shou-Ching S.;Dvorak Harold F. |
分类号 |
C07K16/28;G01N33/68;A61K47/48 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A compound comprising a binding domain that specifically binds to a polypeptide at an epitope comprising an amino acid sequence NYTFASTEGQYLLDTSTWSECTEPKHIVEWNVS (SEQ ID NO: 1). |
地址 |
Boston MA US |