Antibodies Comprising an Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, IL-8-Binding Antibodies, and Uses Thereof

摘要

One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

主权项

1. An antibody comprising an antigen-binding domain whose antigen-binding activity changes according to ion concentration conditions, wherein its isoelectric point (pI) is increased by the modification of at least one amino acid residue that may be exposed on the surface of the antibody, optionally wherein the antigen is a soluble antigen.