| 发明名称 | Bio-hybrid material, production method therefor, and stent | ||
| 摘要 | Provided is a bio-hybrid material that does not cause elution of nickel ions and has an excellent endothelialization ability, a production method therefor, and a stent. The bio-hybrid material (101) used includes an alloy part (11) free of Ni, an organic acid (12) having two or more active esters, and a cytokine (13). The alloy part (11) free of Ni forms an ester bond with the organic acid (12), and the organic acid (12) and the cytokine (13) are immobilized via an amide bond. | ||
| 申请公布号 | US9428588(B2) | 申请公布日期 | 2016.08.30 |
| 申请号 | US201113989279 | 申请日期 | 2011.11.24 |
| 申请人 | National Institute for Materials Science | 发明人 | Taguchi Tetsushi;Sasaki Makoto;Katada Yasuyuki |
| 分类号 | C07K17/14;A61F2/82;A61L31/02;A61L31/16 | 主分类号 | C07K17/14 |
| 代理机构 | Hoffmann & Baron, LLP | 代理人 | Hoffmann & Baron, LLP |
| 主权项 | 1. A bio-hybrid material comprising: an alloy part free of Ni; an organic acid having three or more active ester groups; and a cytokine, wherein the alloy part free of Ni forms an ester bond with the organic acid through one of the three or more active ester groups of the organic acid, and the organic acid and the cytokine are immobilized via an amide bond through active ester groups free of the ester bond with the alloy part free of Ni among the three or more active ester groups of the organic acid. | ||
| 地址 | Ibaraki JP | ||