| 发明名称 |
CLASS OF TRICYCLIC ANALOGUE, PREPARATION METHOD AND USE THEREOF |
| 摘要 |
The present invention relates to a series of analogues having a structure of a natural product Pyripyropene A as represented by formula I, and preparation method and use thereof, and particularly relates to analogues of the natural product Pyripyropene A, preparation method and application thereof in treating cardiovascular diseases such as atherosclerosis, etc. as an inhibitor of an acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2). |
| 申请公布号 |
WO2016145994(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
WO2016CN75391 |
申请日期 |
2016.03.03 |
| 申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
NAN, Fajun;LI, Boliang;ZHAN, Yang;ZHANG, Xiaowei;XIONG, Ying;HU, Xichan;ZHANG, Yangming |
| 分类号 |
C07D493/04;A61K31/4433;A61P9/10 |
主分类号 |
C07D493/04 |
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