发明名称 |
METHODS OF MODULATING AN IMMUNE RESPONSE |
摘要 |
The present invention relates to methods of modulating an immune response in a subject by using a binding protein (e.g., an antibody or an antigen-binding portion of an antibody) to mask or alter an epitope on an antigen that is administered to the subject. Such methods are useful for inducing an immune response (e.g., production of an antibody) in the subject to a non-immunodominant epitope on the antigen. The invention also encompasses an antigen-binding protein complex comprising at least one binding protein bound to at least one immunodominant epitope on an antigen. |
申请公布号 |
EP3107567(A1) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20150751982 |
申请日期 |
2015.02.19 |
申请人 |
Cangene Corporation |
发明人 |
BERRY, Jody;NYKIFORUK, Cory |
分类号 |
A61K39/00;A61K39/02;A61K39/08;A61K39/12;A61K39/395;A61P31/04;A61P31/14;A61P37/04;C07K16/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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