| 摘要 |
<p>NEW MATERIAL:A compound expressed by the formula [R<1> is H or protecting group of amino; R<2> is H or, together with R<3>, forms trimethylene or hydroxytrimethylene; R<3> is (protected group) carboxyalkyl or (protected group) aminoalkyl; X is sulfo, acetylthio or mesyloxyl and salts thereof. EXAMPLE:2-((S)-Benzyloxycarbonylpyrrolidinyl)methyl ethanethioate. USE:A medicine having strengthening and protective action on cardiac muscles. PREPARATION:For example, OH group in a compound expressed by the formula (X is OH) is activated with triphenylphosphine and diethyl azocarboxylat, etc., in a suitable solvent and then allowed so react with thioacetic acid to provide a thioate derivative, which is subsequently sulfonated by oxidation with performic acid, etc., to afford the objective compound expressed by the formula (X is sulfo group).</p> |
