| 发明名称 |
COMPOSITIONS AND METHODS FOR MODIFYING THE REGULATORY ACTIVITY OF TGF- .BETA. |
| 摘要 |
This invention provides a novel purified TGF-.beta. binding glycoprotein, endoglin, and isolated nucleic acid molecules that encode amino acid sequences corresponding to the TGF-.beta.-binding glycoprotein. Also provided is soluble endoglin-derived polypeptide, and fragments thereof. A pharmaceutical composition which comprises the purified endoglin-derived polypeptide or produced recombinantly methods and a pharmaceutically acceptable carrier is further provided as well as methods of treating patients by administering to the patient the pharmaceutical compositions of this invention.
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| 申请公布号 |
CA2147754(A1) |
申请公布日期 |
1994.05.11 |
| 申请号 |
CA19932147754 |
申请日期 |
1993.10.26 |
| 申请人 |
HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP;MEMORIAL SLOAN-KETTERING CANCER CENTER;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS |
发明人 |
LETARTE, MICHELLE;MASSAGUE, JOAN;BERNABEU, CARMELO;CHEIFETZ, SELA |
| 分类号 |
C12N15/09;A61K38/00;A61P1/00;A61P1/16;A61P9/10;A61P29/00;A61P37/00;A61P43/00;C07H21/02;C07H21/04;C07K14/47;C07K14/71;C07K16/28;C12N5/10;C12P21/02;(IPC1-7):C12N15/12;A61K38/17;A61K38/18;C07K14/435 |
主分类号 |
C12N15/09 |
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