发明名称 |
SUBSTITUTED ARYL PIPERAZINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
摘要 |
The present invention is directed to aryl piperazines of formula (I) (wherein Ar, R1, R8 and R9 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
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申请公布号 |
WO9825617(A1) |
申请公布日期 |
1998.06.18 |
申请号 |
WO1997US22769 |
申请日期 |
1997.12.12 |
申请人 |
MERCK & CO., INC.;MILLS, SANDER, G.;SPRINGER, MARTIN, S.;MACCOSS, MALCOLM |
发明人 |
MILLS, SANDER, G.;SPRINGER, MARTIN, S.;MACCOSS, MALCOLM |
分类号 |
A61K31/495;A61K31/496;A61K31/497;A61K31/506;(IPC1-7):A61K31/495;A61K31/50 |
主分类号 |
A61K31/495 |
代理机构 |
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