New 2-((heteroaralkyl)-amino)-benzamide derivatives, are vascular endothelial growth factor (VEGF) receptors, KDR kinase and FLT kinase inhibitors useful for e.g. treating tumors, psoriasis, arthritis or renal diseases

摘要

N-(Cyclo)alkyl-2-((heteroaralkyl)-amino)-benzamide derivatives (I) (including thioamide, amine, amidine or hydrazide analogs) are new. N-(Cyclo)alkyl-2-((heteroaralkyl)-amino)-benzamide derivatives (I) (including thioamide, amine, amidine or hydrazide analogs) of formula (I) and their isomers and salts are new. W = O, S, H2 or NR8; Z' = direct bond, NR10 or N; R1 = 1-12C alkyl, 2-12C alkenyl, 3-10C cycloalkyl or 3-10C cycloalkenyl (all optionally substituted by one or more halo, OH, OT, aralkoxy, T and/or NR11R12); X = 1-6C alkylene; R2 = mono- or bicyclic heteroaryl (optionally substituted by one or more of halo, T, OT and/or OH); R3-R6 = H, halo, or OT, T or (1-6C) carboxyalkyl (all optionally substituted by one or more halo); R7 = H, T or 1-8C (sic) cycloalkyl; R8-R12 = H or T; or NR11R12 = ring (optionally containing a further heteroatom and optionally substituted by T); and T = 1-6C alkyl.