发明名称 |
PROCESS FOR PRODUCING LARGE CYCLIC KETONE AND INTERMEDIATE THEREFOR |
摘要 |
A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentration but under practical condition. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper or nickel catalyst and an enol anion scavenger to obtain a 3-methyl-1-cyclopentadecene derivative represented by General Formula (II) and then solvolyzing the enol moiety of the 3-methyl-1-cyclopentadecene derivative to obtain muscone. |
申请公布号 |
EP1845078(A1) |
申请公布日期 |
2007.10.17 |
申请号 |
EP20040799627 |
申请日期 |
2004.11.11 |
申请人 |
TAKASAGO INTERNATIONAL CORPORATION |
发明人 |
MATSUDA, HIROYUKI;TANAKA, SHIGERU |
分类号 |
C07C67/08;C07C45/51;C07C45/54;C07C49/385;C07C68/06;C07C69/013;C07C69/96 |
主分类号 |
C07C67/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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