| 主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure: wherein: L1 is L2 is selected from the group consisting of A is selected from the group consisting of an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; Y is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R1a is hydrogen or an unsubstituted C1-4 alkyl; R2a and R2a1 are each independently hydrogen or an unsubstituted C1-4 alkyl; R3a and R3a1 are each independently hydroxy, CHF2, CF3 or NH2; R4a, R4a1 and R4a2 are independently selected from the group consisting of hydrogen, halogen, hydroxy, an optionally substituted C1-8 alkyl, an optionally substituted C1-8 alkoxy and haloalkyl; R5a1 and R5a3 are independently an unsubstituted C1-6 alkyl, an unsubstituted C3-6 cycloalkyl, or —(CH2)1-4OH; R5a2 and R5a4 are independently hydrogen, hydroxy, an unsubstituted C1-6 alkyl, an optionally substituted monocyclic heterocyclyl, —C(═O)R5a5, an unsubstituted —C-amido, —C(═NH)-an unsubstituted C1-6 alkyl; or R5a1 and R5a2 are taken together with the atoms they are attached to form an optionally substituted 4 to 6 membered ring; R5a3 and R5a4 are taken together with the atoms they are attached to form an optionally substituted 4 to 6 membered ring; R5a5 is an unsubstituted C1-4 alkyl; each R6a1, each R6a2, each R6a3 and each R6a4 are independently selected from the group consisting of hydrogen, halogen, an unsubstituted C1-6 alkyl and hydroxy; R6a5 is selected from the group consisting of halogen, an unsubstituted C1-6 alkyl and hydroxy; R7a and R8a are each independently an unsubstituted C1-6 alkyl; R9a1, R9a2, R10a and R11a are independently hydrogen or an unsubstituted C1-6 alkyl; Z1 is O or S; Z2 is O, NRZ or CRZ1RZ2; Z3 is O, NRZ3 or CRZ4RZ5; Z4 is O, NRZ6 or CRZ7RZ8; RZ, RZ1, RZ2, RZ3, RZ4, RZ5, RZ6, RZ7 and RZ8 are independently hydrogen or an unsubstituted C1-4 alkyl; p and q are independently 1 or 2; and provided that when L1 isand L2 isthen one of R3a and R3a1 is NH2, and the other of R3a and R3a1 is OH;
provided that when L1 isL2 isone of R3a and R3a1 is CF3, and other of R3a and R3a1 is OH, then Y isand A is a disubstituted phenyl wherein one substituent isand the other substituent is —O—(CH2)2-4OH orand
provided the compound of Formula (I) is not any one of the group consisting of:or a pharmaceutically acceptable salt of the foregoing. |
