Prosthesis with sustained release analgesic

摘要

A device for releasing a therapeutic agent in the body space in the form of a prosthetic joint implant having a first portion such as a stemmed portion for contacting bone tissue in an intramedullary canal of a long bone. The implant has a second portion which extends into the body space such as a joint space. The joint component contains a reservoir filled with a bioabsorbable/resorbable polymer which includes a therapeutic agent. The reservoir is open or in contact with the joint space as the body fluid diffuses in and out of the polymeric device it carries the drug into the joint space.

主权项

1. A prosthetic joint implant device for releasing a therapeutic agent into a joint space comprising:
(a) a stem component for insertion into a bone, contiguous with (b) a joint component for extension into a fluid-containing joint space; and (c) a cavity enclosed within the stem and joint components that (i) extends from the stem component into the joint component, having an opening in the joint component and (ii) serves as a reservoir, containing a bioresorbable polymer comprising a therapeutic agent selected from the group consisting of an analgesic, an antibiotic, and a combination thereof;wherein the device is configured such that, when at its intended location in a subject, the opening of the reservoir is at a position in the joint component that extends beyond the bone and into the joint space, such that the opening allows joint fluid to diffuse into the device, providing sustained release of agent.