DEAD BOX RNA HELICASE DDX3 AS A THERAPEUTIC TARGET IN COLORECTAL CANCER AND METHODS OF TREATMENT THEREOF

摘要

The present invention provides methods for down regulation of DDX3 in colorectal cancer cells by administration of an effective amount of a DDX3 inhibitor such as RK-33 or a salt, solvate, or derivative thereof. The present invention also provides uses of the DDX3 inhibitor such as RK-33 for treatment of colorectal disease in a subject.