Surface-modified heavy metal nanoparticles, compositions and uses thereof

摘要

Surface-modified heavy metal nanoparticles, including a heavy metal core and a coating layer, the coating layer having at least one ligand, conjugated to polyethylene glycol, the at least one ligand is selected from N-acetyl cysteine, albumin, cysteine, methionine, glutathione, amino thiols, thio-carboxylic acids, ammonia, amines, diamines or any combination thereof. Compositions including surface-modified heavy metal nanoparticles and uses thereof in treatment and diagnosis of various conditions.

主权项

1. An aqueous dispersion comprising:
surface-modified metal nanoparticles comprising a metal core and a coating layer, the coating layer comprising at least one ligand bound to the surface of the metal core and conjugated to polyethylene glycol (PEG), wherein the at least one ligand is selected from the group consisting of free N-acetyl cysteine (NAC), albumin, free cysteine, free methionine, free glutathione, amino thiols, thio-carboxylic acids, ammonia, amines, diamines and any combination thereof, wherein the nanoparticles are dispersed in water or in a buffer.