发明名称 |
METHOD FOR THE RESOLUTION OF FOLINIC ACID |
摘要 |
A process is provided for separating diastereomers of (6R,S)-folinates. The process includes adding a sufficient amount of a water-soluble alkali metal salt of an inorganic acid or of an organic acid or a water-soluble ammonium salt of an inorganic acid or of an organic acid to an aqueous starting solution of an alkali metal salt of (6R,S)-folinic acid or an alkaline earth metal salt of (6R,S)-folinic acid at a neutral pH to precipitate the (6R)-folinate. The resultant (6R)-folinate precipitate is then separated off. The (6S)-folinate is then isolated from the filtrate.
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申请公布号 |
CA2002430(C) |
申请公布日期 |
1997.03.04 |
申请号 |
CA19892002430 |
申请日期 |
1989.11.07 |
申请人 |
EPROVA AG |
发明人 |
MUELLER, HANS RUDOLF;ULMANN, MARTIN;CONTI, JOSEF;MUERDEL, GUENTER |
分类号 |
C07D475/04;(IPC1-7):C07D475/04 |
主分类号 |
C07D475/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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