USE OF alpha -MSH AND EPO FOR PREVENTING OR TREATING ISCHEMIC CONDITIONS

摘要

The present invention relates to a method for treating or preventing ischemia induced organ dysfunction. The method comprises administration of an effective dose of alpha -MSH and/or an alpha -MSH equivalent and EPO and/or an EPO equivalent to an individual in need thereof. Examples of ischemic conditions, which may be treated according to the present invention, are: Ischemia induced renal failure, myocardial ischemia, intestinal ischemia and cerebral ischemia. In various animal models of ischemia the combination of alpha -MSH and rh-EPO has been shown to have a synergistic effect in reversing the adverse effects of the ischemia.