MATERIALS AND METHODS RELATING FOR THE TREATMENT AND DIAGNOSIS OF PRE-ECLAMPSIA

摘要

The present invention relates to use of GPI-PLD antagonists for the prevention, treatment and diagnosis of pre-eclampsia. The substantial GPI-PL D activity is present in the placenta in pre-eclampsia is not expressed in the placenta, but rather is taken up from the maternal circulation. As a result, abnormal or dysregulated GPI-PLD activity present in the placenta in pre- eclampsia may be correctable by administration of GPI-PLD to the mother to correct the problems caused by abnormal or dysregulated GPI-PLD, e.g. to reduce the abnormal release and in situ production of placental IPGs involve d in the pathogenesis of pre-eclampsia. This can be achieved using exogenous G PI- PLD or a fragment thereof, e.g. an inactive GPI-PLD capable of competing wit h or displacing the abnormal or dysregulated GPI-PLD, e.g. from Apo-A1.