发明名称 |
USE OF EGF-R PROTEIN TYROSINE KINASE INHIBITORS FOR PREVENTING PHOTOAGING IN HUMAN SKIN |
摘要 |
Photoaging of human skin, such as evidenced by the increased presence of matrix metalloproteinases after exposure to UV radiation, is prevented by pr e- treating the skin with an inhibitor of epideremal growth factor receptor (EG F- R) prior to exposure. Such inhibitors are preferably natural, an example of which is geniestein. Compositions used for such purposes preferably include an EGF-R inhibitor as well as another MMP inhibitor, such as a retinoid.</SDOAB >
|
申请公布号 |
CA2414406(A1) |
申请公布日期 |
2002.01.03 |
申请号 |
CA20012414406 |
申请日期 |
2001.06.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
VOORHEES, JOHN J.;FISHER, GARY J. |
分类号 |
A61K8/00;A61K8/49;A61K31/07;A61K31/203;A61K31/352;A61P17/16;A61P43/00;A61Q17/04;A61Q19/08;(IPC1-7):A61K7/42;A61K31/35;A61K7/48 |
主分类号 |
A61K8/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|