摘要 |
Compositions and methods are provided for achieving the deaggregation of binding proteins including, but not limited to, protein ligands, soluble receptors, antibodies, antibody fragments, variable fragment single-chain antibodies (scFv), and small modular immunopharmaceutical products (SMIP products). The compositions, which are suitable for the deaggregation of highly concentrated solutions of binding proteins, contain one or more chaotrope, are typically formulated at an acidic pH, and may be used to provide binding proteins suitable for the preparation of pharmaceutical compositions and administration in vivo to a patient. |
申请人 |
TRUBION PHARMACEUTICALS, INC.;MOVIUS IV, ARTHUR, JAMES;DUA, RAJESH |
发明人 |
MOVIUS IV, ARTHUR, JAMES;DUA, RAJESH |