主权项 |
1. A compound of the formula or a pharmaceutically acceptable salt thereof; wherein a dashed line represents the presence or absence of a bond; Y is selected from CO2R2, CON(R2)2, CON(OR2)R2, CON(CH2CH2OH)2, CONH(CH2CH2OH), CH2OH, P(O)(OH)2, CONHSO2R2, SO2N(R2)2, SO2NHR2, wherein R2 is independently H, C1-C6 alkyl, unsubstituted phenyl, or unsubstituted biphenyl; A is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is —(CH2)m—Ar—(CH2)o— wherein Ar is phenyl or thienyl, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or C≡C—; U1 and U2 are independently H, O; OH, I, Br, Cl, F, CF3, CN, or CH2OH; J is U3 is I, Br, Cl, F, CN, C1-6 alkyl, aryl, heteroaryl, or C1-6 hydroxyalkyl; and B is aryl or heteroaryl. |