Treatment of specific cardiovascular conditions with nitrite

摘要

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

主权项

1. A method for treating pulmonary hypertension in a subject in need thereof by decreasing pulmonary arterial blood pressure or increasing vasodilation, or both, the method comprising administering by inhalation a therapeutically effective amount of pharmaceutically acceptable non-acidified sodium nitrite to the subject to decrease the pulmonary artery blood pressure, or increase vasodilation, or both, in the subject, thereby treating pulmonary hypertension.