Cross-linking composition delivered by iontophoresis, useful for the treatment of keratoconus

摘要

An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.

主权项

1. An ophthalmic composition useful for the treatment of keratoconus to be administered by corneal iontophoresis, wherein the cross-linking agent is riboflavin, the pH is between 6.9 and 7.2, and the value of osmolarity is between 90 and 100 mOsm/l, and the following formulation:Riboflavin sodium phosphate0.147gSodium-EDTA0.1gTris-(hydroxymethyl)aminomethane0.05gNaH2PO4•2H2O0.385gNa2HPO4•2H2O0.217gDistilled waterup to 100g.