Immune response inducer

摘要

An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).

主权项

1. A method for exerting an anti-tumor effect, said method comprising administering to a cancer-bearing individual an effective amount of polypeptide (a) or (b) below, said polypeptide having an immunity-inducing activity, or administering to a cancer-bearing individual an effective amount of a recombinant vector, wherein said recombinant vector comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo:
(a) a polypeptide comprising the amino acid sequence shown in SEQ ID NO:16, or SEQ ID NO:18; (b) a polypeptide having a homology of not less than 95% to SEQ ID NO:16 or SEQ ID NO:18 which has immunity inducing activity, and wherein said cancer is calmegin-expressing cancer.