METHOD FOR THE QUANTITATIVE CHARACTERIZATION OF AMYLOID AND/OR AGGREGATING PEPTIDES AND/OR PROTEINS IN A SAMPLE

摘要

A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising: providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape; adding an active ingredient to be analyzed to the sample solution; separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape; optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks; determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.

主权项

1. A method for the quantitative characterization of amyloid and/or aggregating peptides and/or proteins in a sample, comprising the steps of:
1. providing a sample, wherein the sample includes an amyloid and/or aggregating peptide and/or protein having at least one aggregate size and shape; 2. adding an active ingredient to be analyzed to the sample solution; 3. separating the amyloid and/or aggregating peptides and/or proteins from one another according to their aggregate size and shape; and 4. determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by a comparison against control values without the active ingredient.